Sickle cell disease by Prof. Martin H. Steinberg Boston University Chobanian & Avedisian School of Medicine, USA

A 50-minute multimedia lecture titled "Sickle Cell Disease" by Prof. Martin H. Steinberg from Boston University Chobanian & Avedisian School of Medicine, USA, comprehensively covers various aspects of sickle cell disease (SCD). The Lecture begins with disclosures and a timeline of discovery related to SCD and progresses to discuss the molecular basis of the disease, including the structure and mutation of globin genes. Prof. Martin H. Steinberg delves into the pathophysiology of SCD, focusing on HbS polymerization, membrane damage, and the formation of irreversibly sickled cells (ISCs). The Lecture also explores inheritance patterns, diagnosis, and common complications associated with SCD. Furthermore,  Prof. Martin H. Steinberg addresses treatment options, including hydroxyurea therapy, hematopoietic stem cell transplantation, and emerging strategies such as gene therapy and gene editing. The importance of targeting HbF gene expression and the potential for a cure with sufficient HbF/RBC levels are also discussed.