The Noradrenergic hypothesis of Neurodegeneration and Astroglia by Prof. Robert Zorec University of Ljubljana, Slovenia

The multimedia lecture titled "Noradrenergic Hypothesis of Neurodegeneration and Astroglia" is explained in  37 minutes by Prof. Robert Zorec from the University of Ljubljana, Slovenia, delves into the role of noradrenaline and astroglia in neurodegeneration, particularly focusing on Alzheimer's disease (AD) and TDP-43 proteinopathies. The lecture begins with an exploration of how thinking is measured and the relationship between pupil diameter and neuronal activity. It discusses the pathophysiology of AD and introduces the Seattle Alzheimer's disease brain cell atlas (SEA-AD). The lecture highlights the role of astrocytes and the locus coeruleus (LC) in neuropathology, emphasizing astroglial morphological plasticity and the excitable nature of astrocytes. Furthermore, it examines the impact of adrenergic stimulation on astrocytic aerobic glycolysis and lipid droplet accumulation, proposing a noradrenergic hypothesis of neurodegeneration. The lecture concludes with acknowledgments. For further details, watch a video