The title "Neurotransmitter Receptor Auxiliary Subunits", is presented in a 38 minute lecture by Dr. Javier Diaz Alonso from the University of California, Irvine, various key topics in the field of synaptic transmission and receptor modulation are discussed. The lecture gives insight into the intricate mechanisms of synapses, exploring concepts such as long-term potentiation and the role of ionotropic receptors, particularly ligand-gated ion channels such as AMPA receptors. It also elaborates on the significance of auxiliary subunits in receptor function, including AMPAR auxiliary proteins and their modulation of channel gating. The discussion extends to TARPs (Transmembrane AMPAR Regulatory Proteins) and their involvement in AMPAR trafficking, shedding light on the TARP PBM (PDZ-binding motif) role in both AMPAR trafficking and long-term potentiation. He also touches upon artificial PDZ-PBM and PBM-independent TARP roles in AMPAR trafficking, emphasizing the multivalent interaction between TARPs and PSD-95. Furthermore, the presentation expands to cover other AMPAR auxiliary proteins, including Cornichon homologs and GSG1L, as well as exploring auxiliary proteins in other receptors such as Kainate receptors and Netos. Dr. Alonso concludes by highlighting the therapeutic potential of targeting auxiliary subunits in the context of synaptic modulation. For further details, watch a video