Importance of Nutrition and Weight Loss in Motor Neuron Disease", is explained in a 21 minute presentation by Dr. Luc Dupuis from the Université de Strasbourg, France, the metabolic component of Amyotrophic Lateral Sclerosis (ALS) is thoroughly explored. Dr. Dupuis highlights that ALS exhibits a significant metabolic aspect, evident in weight loss and impaired energy metabolism associated with ALS mutations. Notably, weight loss is observed years before the onset of motor symptoms, and this phenomenon is replicated in ALS mouse models. The lecture raises critical questions regarding the potential targeting of weight loss and metabolic abnormalities for ALS treatment, emphasizing the predictive value of weight loss for survival. Investigating dietary interventions, Dr. Dupuis discusses how a high-calorie diet can increase the survival of ALS mice and introduces the concept of LIPCAL-ALS. The progression of ALS is closely linked to weight loss, prompting a focus on understanding the key cell types driving this phenomenon. The lecture explores into the hypothalamus and its nuclei, correlating hypothalamic volume alterations, especially in the lateral hypothalamic area (LHA), with body mass index (BMI). Furthermore, Dr. Dupuis explores the degeneration of melanin-concentrating hormone (MCH) neurons in the LHA and its impact on food intake in mutant SOD1 mice. The presentation concludes with a discussion on potential pharmacological strategies to address the metabolic aspects of ALS.For further details, watch a video